top of page

VIPRE

Virus Infection Preparedness

Logo_en.webp

Dear Scientists,

 

Among zoonotic pathogens, the Nipah virus and the Crimean-Congo Hemorrhagic Fever (CCHF) virus are notable for their high pathogenic characteristics and pandemic potential, posing serious threats to global health security. The Nipah virus, with its neurotropic nature, leads to severe respiratory illnesses and encephalitis, while the CCHF virus frequently results in severe and often fatal hemorrhagic fevers. Due to their capability for human-to-human transmission, high mortality rates, and the absence of effective vaccines or antiviral treatments, both viruses are classified under the highest biosafety level, BSL-4.

 

The CCHF virus, endemic in 49 countries across Africa, the Middle East, and Asia, primarily spreads through ticks. Conversely, recent outbreaks of the Nipah virus in Kerala, India, highlight its unpredictable nature and the urgent need for immediate intervention. The severity of infections caused by these viruses could signal the onset of a global pandemic, necessitating a multidisciplinary approach.

 

In response to this critical situation, the VIPRE Project aims to address the existing gaps in research on the Nipah and CCHF viruses through a multidisciplinary approach. The project integrates high-resolution biophotonic imaging and vibrational spectroscopy techniques to offer new perspectives on these infections. The research encompasses four main themes: changes occurring in host cells during and after virus entry; factors influencing host cell responses to viral entry; development of neutralizing monoclonal antibodies; and optimization of nanoparticle-based vaccine candidates.

 

By combining molecular and advanced imaging techniques, the VIPRE Project seeks to fundamentally understand how viruses interact with cellular structures, thereby facilitating a better comprehension of viral pathogens. The project aims to identify host-specific factors that influence infection outcomes, providing significant insights into disease dynamics.

 

VIPRE plays a crucial role in developing therapeutic steps, aiming to contribute to pandemic preparedness and response strategies. In this context, the priority is to develop antibody-based treatments capable of neutralizing viral infections and reducing disease severity.

 

Furthermore, the project emphasizes a commitment to open science practices and real-world impact, aiming to create a comprehensive database and activity map. This holistic approach can provide a deeper understanding of the subject and lead to more effective outcomes. Ultimately, the VIPRE Project, through collaboration among experts in virology, chemistry, biophysics, statistics, and other disciplines, aims to develop innovative strategies against viral infections and add value to health systems. This project, including technologies such as artificial intelligence and machine learning, is part of the effort to create a world better prepared for pandemics. We extend our deepest thanks to everyone who has contributed to this project.

Partners

bottom of page